Meilin Xie Selected Research

osthol (osthole)

1/2019	Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured hepatocytes.
4/2018	PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats.
1/2013	Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II.
5/2011	Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress.
2/2011	Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats.
7/2007	Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.

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Meilin Xie Research Topics

Disease

6	Fatty Liver 04/2018 - 07/2007
4	Fibrosis (Cirrhosis) 01/2022 - 09/2012
3	Hypoxia (Hypoxemia) 01/2022 - 01/2019
2	Insulin Resistance 01/2019 - 02/2011
2	Alcoholic Fatty Liver 01/2019 - 05/2011
2	Non-alcoholic Fatty Liver Disease 04/2018 - 03/2017
2	Inflammation (Inflammations) 04/2018 - 02/2011
1	Neoplasms (Cancer) 01/2022
1	Glioma (Gliomas) 01/2022
1	Ureteral Obstruction 12/2020
1	Body Weight (Weight, Body) 02/2011
1	Rupture 01/2009
1	Atherosclerotic Plaque (Atheroma) 01/2009

Drug/Important Bio-Agent (IBA)

6	osthol (osthole)IBA 01/2019 - 07/2007
6	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2019 - 02/2011
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2015
3	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2022 - 09/2012
3	CollagenIBA 01/2022 - 09/2012
2	ApigeninIBA 01/2022 - 01/2022
2	EnzymesIBA 01/2022 - 05/2011
2	Hydroxyproline (4 Hydroxyproline)IBA 12/2020 - 09/2012
2	LipidsIBA 01/2019 - 05/2011
2	EmulsionsIBA 04/2018 - 02/2011
2	Triglycerides (Triacylglycerol)IBA 04/2018 - 03/2017
2	Sucrose (Saccharose)IBA 04/2018 - 02/2011
2	Messenger RNA (mRNA)IBA 09/2015 - 07/2007
2	Therapeutic UsesIBA 05/2011 - 07/2007
1	IsoenzymesIBA 01/2022
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2022
1	NF-kappa B (NF-kB)IBA 01/2022
1	Pyruvate KinaseIBA 01/2022
1	steviosideIBA 12/2020
1	NitrogenIBA 12/2020
1	Urea (Carbamide)FDA LinkGeneric 12/2020
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2019
1	FlavonoidsIBA 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2019
1	Angiotensin IIIBA 01/2019
1	CoumarinsIBA 01/2019
1	LuteolinIBA 01/2019
1	Pyruvic Acid (Pyruvate)IBA 01/2019
1	Interleukin-8 (Interleukin 8)IBA 04/2018
1	Nonesterified Fatty Acids (NEFA)IBA 04/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2018
1	Interleukin-6 (Interleukin 6)IBA 04/2018
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 04/2018
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 09/2015
1	Acetyl-CoA CarboxylaseIBA 09/2015
1	CholesterolIBA 03/2014
1	SterolsIBA 03/2014
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 03/2014
1	ElementsIBA 03/2014
1	PolyphenolsIBA 03/2014
1	Matrix Metalloproteinases (MMPs)IBA 01/2013
1	puerarinIBA 09/2012
1	IsoflavonesIBA 09/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2011
1	AdiponectinIBA 02/2011
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2009
1	Cholesterol 7-alpha-Hydroxylase (Cholesterol 7 alpha Hydroxylase)IBA 07/2007
1	PPAR alphaIBA 07/2007

Therapy/Procedure

3	Aftercare (After-Treatment) 01/2022 - 02/2011
1	Radiotherapy 01/2022